androidsixteen
@androidsixteen.eth
It’s ironic that we’re simultaneously acknowledging the downsides of plastics and promoting GLP-1 meds It’s the hubris of a materially advanced society — we can’t fathom how engineering our materials and our bodies could be bad for us Though the negatives of GLPs will likely be discovered sooner (spoiler alert: muscle loss)
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keccers
@keccers.eth
Muscle loss happens with all weight loss though.
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androidsixteen
@androidsixteen.eth
Muscle loss seems to be higher with GLPs relative to non-pharma interventions, and I don’t know if we have enough research on how it affects other lean mass like bones and organs “Studies suggest muscle loss with these medications (as indicated by decreases in fat-free mass [FFM]) ranges from 25% to 39% of the total weight lost over 36–72 weeks. This substantial muscle loss can be largely attributed to the magnitude of weight loss, rather than by an independent effect of GLP-1 receptor agonists, although this hypothesis must be tested. By comparison, non-pharmacological caloric restriction studies with smaller magnitudes of weight loss result in 10–30% FFM losses.” https://www.thelancet.com/journals/landia/article/PIIS2213-8587(24)00272-9/abstract
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keccers
@keccers.eth
Overblown nonsense made up by people that just want to see fat people suffer and “earn” their weight loss
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androidsixteen
@androidsixteen.eth
Yes you’re right, let’s just ape into experimental hormone therapy Feels like you’re overfitting from your about face on SSRIs
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androidsixteen
@androidsixteen.eth
Also here’s some more anecdotal data on muscle loss (in the SMAS), from you: https://warpcast.com/keccers.eth/0x8099fdff Do you really think medically induced deterioration is best for people who are already suffering?
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keccers
@keccers.eth
No I just know how bad it is to be fat. And I think it’s easy for a thinner person to finger wag about muscle loss while ignoring the risk benefit analysis. The all cause mortality risk reduction from the weight loss is so great and the muscle loss sfx is mitigable. And you’re going to deny people that all cause mortality risk reduction make it make sense? It just reads to me like you want them to suffer and why
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