It’s ironic that we’re simultaneously acknowledging the downsides of plastics and promoting GLP-1 meds

It’s the hubris of a materially advanced society — we can’t fathom how engineering our materials and our bodies could be bad for us

Though the negatives of GLPs will likely be discovered sooner (spoiler alert: muscle loss)

Muscle loss happens with all weight loss though.

Muscle loss seems to be higher with GLPs relative to non-pharma interventions, and I don’t know if we have enough research on how it affects other lean mass like bones and organs 

“Studies suggest muscle loss with these medications (as indicated by decreases in fat-free mass [FFM]) ranges from 25% to 39% of the total weight lost over 36–72 weeks. This substantial muscle loss can be largely attributed to the magnitude of weight loss, rather than by an independent effect of GLP-1 receptor agonists, although this hypothesis must be tested. By comparison, non-pharmacological caloric restriction studies with smaller magnitudes of weight loss result in 10–30% FFM losses.”

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Muscle loss seems to be higher with GLPs relative to non-pharma interventions, and I don’t know if we have enough research on how it affects other lean mass like bones and organs 

“Studies suggest muscle loss with these medications (as indicated by decreases in fat-free mass [FFM]) ranges from 25% to 39% of the total weight lost over 36–72 weeks. This substantial muscle loss can be largely attributed to the magnitude of weight loss, rather than by an independent effect of GLP-1 receptor agonists, although this hypothesis must be tested. By comparison, non-pharmacological caloric restriction studies with smaller magnitudes of weight loss result in 10–30% FFM losses.”

https://www.thelancet.com/journals/landia/article/PIIS2213-8587(24)00272-9/abstract

Overblown nonsense made up by people that just want to see fat people suffer and “earn” their weight loss

Yes you’re right, let’s just ape into experimental hormone therapy 

Feels like you’re overfitting from your about face on SSRIs

No I just know how bad it is to be fat. And I think it’s easy for a thinner person to finger wag about muscle loss while ignoring the risk benefit analysis. 

The all cause mortality risk reduction from the weight loss is so great and the muscle loss sfx is mitigable. And you’re going to deny people that all cause mortality risk reduction make it make sense? It just reads to me like you want them to suffer and why

No one serious promotes it as a miracle cure nor claims you have to take it forever. Loser techbros say “put it in the water supply” and shitty influencers take it for vanity weight loss. All unserious 

You can go off these drugs and maintain weight loss, and many have done it. It seems to largely depend on if you were able to build healthy habits like exercise while you were on it https://epicresearch.org/articles/many-patients-maintain-weight-loss-a-year-after-stopping-semaglutide-and-liraglutide

This is a non surgical avenue for weight loss that works and has been in market for a decade +. I say you want suffering because that is to me is what it is — taking this away from people who know the risks and are basically down horrendous already from the obesity itself

I don’t want anyone to suffer, your framing is really aggressive

I just don’t think we have the data to promote this drug in the way it’s been promoted (a miracle cure)

You also literally can’t stop taking it, ever (which means it has great economics)

So yes, I think we need to be default skeptical — don’t conflate that with wishing suffering for anyone