It’s ironic that we’re simultaneously acknowledging the downsides of plastics and promoting GLP-1 meds

It’s the hubris of a materially advanced society — we can’t fathom how engineering our materials and our bodies could be bad for us

Though the negatives of GLPs will likely be discovered sooner (spoiler alert: muscle loss)

100%

The words “the obstacle is the way” come to mind 

Maybe object proliferation (enabled by platics), though convenient, wasn’t the best for us

Similarly about inducing arbitrary weight loss without a shift in lifestyle

humans like max convenience whether enabled by plastics or meds or something else

then they realize

Maybe Convenience Bad

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I think this is flawed logic though 

Until you face the underlying problem, all you’re doing is distorting it and shaping it into something unseen

What is the long term effect of a population that has eaten its own muscle mass (including cardiac muscle)? I imagine courage and the ability to tackle problems will be lacking

at the margin, probably better to have a skinnier society and then solve for the issues that arise once we've cured obesity

https://www.sciencedirect.com/science/article/pii/S2452302X24002869

“While these findings are promising for CV patients, a side-effect of GLP-1RAs use is the loss of skeletal muscle (lean BW) mass.”

“Overall, these data show that semaglutide has an effect on the cardiomyocyte resulting in reduced cardiomyocyte size and cardiac mass in lean and obese mice”

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Question about the muscle loss comment, have you read something recently?

I haven't looked into all this so I am not up to date.

Educational guess I'd say it's in relationship to losing weight doing nothing as opposed to previously people would actually work out etc...

Muscle loss seems to be higher with GLPs relative to non-pharma interventions, and I don’t know if we have enough research on how it affects other lean mass like bones and organs 

“Studies suggest muscle loss with these medications (as indicated by decreases in fat-free mass [FFM]) ranges from 25% to 39% of the total weight lost over 36–72 weeks. This substantial muscle loss can be largely attributed to the magnitude of weight loss, rather than by an independent effect of GLP-1 receptor agonists, although this hypothesis must be tested. By comparison, non-pharmacological caloric restriction studies with smaller magnitudes of weight loss result in 10–30% FFM losses.”

https://www.thelancet.com/journals/landia/article/PIIS2213-8587(24)00272-9/abstract

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I’m not sure the muscle loss is entirely pro forma GLP but subsequent success of the drug itself.

Kinda like how Viagra was originally researched for chest pain and hypertension.

Overblown nonsense made up by people that just want to see fat people suffer and “earn” their weight loss

No, because saying anything bad about GLPs means you want fat people to suffer (according to @keccers.eth)

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No, because saying anything bad about GLPs means you want fat people to suffer (according to @keccers.eth)

https://warpcast.com/keccers.eth/0x69617a76

The modern world has given us some really amazing things but man have we lost sight because of it all.

Can we all please just go back to the most natural and basic ways of eating and caring for ourselves ?😩

Watching some family members become so frail from GLPs and having no interest in understanding the negative effects is the epitome of ✨stress✨

it would be ironic if creating fat was an appropriate/healthy biological response to sequestering some prevalent environmental toxin and reducing that fat w/o dealing with the env toxin lead to worse outcomes longer term..

I think medical agency is at ATLs right now

Also it’s really hard work losing weight “the ol’ fashioned way”, especially when you’re being poisoned with plastics

With my discussions with doctors in the past they are waiting to see the long term effects as they say it's too early to tell...

So ya... We're allowing ourselves to be guinea pigs... Why? I think motivated by vanity... People in power feel that important?

I don't know...

Muscle loss seems to be higher with GLPs relative to non-pharma interventions, and I don’t know if we have enough research on how it affects other lean mass like bones and organs 

“Studies suggest muscle loss with these medications (as indicated by decreases in fat-free mass [FFM]) ranges from 25% to 39% of the total weight lost over 36–72 weeks. This substantial muscle loss can be largely attributed to the magnitude of weight loss, rather than by an independent effect of GLP-1 receptor agonists, although this hypothesis must be tested. By comparison, non-pharmacological caloric restriction studies with smaller magnitudes of weight loss result in 10–30% FFM losses.”

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Muscle loss happens with all weight loss though.

100%

Contemporary society loves a quick fix. And then a quick fix for the problems caused by first quick fix and so on. It’s bandaids all the way down.

It’s #1 reason I can’t bring myself to recover my former techno optimism. At some point the whole disgusting mess is going to fall off and the failure to address the root cause of things will become painfully apparent.

It’s crazy how we often overlook the long-term effects of both tech and health advancements. GLP-1 meds might be a short-term fix, but muscle loss seems like a big red flag.