androidsixteen
@androidsixteen.eth
It’s ironic that we’re simultaneously acknowledging the downsides of plastics and promoting GLP-1 meds It’s the hubris of a materially advanced society — we can’t fathom how engineering our materials and our bodies could be bad for us Though the negatives of GLPs will likely be discovered sooner (spoiler alert: muscle loss)
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keccers
@keccers.eth
Muscle loss happens with all weight loss though.
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androidsixteen
@androidsixteen.eth
Muscle loss seems to be higher with GLPs relative to non-pharma interventions, and I don’t know if we have enough research on how it affects other lean mass like bones and organs “Studies suggest muscle loss with these medications (as indicated by decreases in fat-free mass [FFM]) ranges from 25% to 39% of the total weight lost over 36–72 weeks. This substantial muscle loss can be largely attributed to the magnitude of weight loss, rather than by an independent effect of GLP-1 receptor agonists, although this hypothesis must be tested. By comparison, non-pharmacological caloric restriction studies with smaller magnitudes of weight loss result in 10–30% FFM losses.” https://www.thelancet.com/journals/landia/article/PIIS2213-8587(24)00272-9/abstract
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keccers
@keccers.eth
Overblown nonsense made up by people that just want to see fat people suffer and “earn” their weight loss
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androidsixteen
@androidsixteen.eth
Yes you’re right, let’s just ape into experimental hormone therapy Feels like you’re overfitting from your about face on SSRIs
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androidsixteen
@androidsixteen.eth
Also here’s some more anecdotal data on muscle loss (in the SMAS), from you: https://warpcast.com/keccers.eth/0x8099fdff Do you really think medically induced deterioration is best for people who are already suffering?
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keccers
@keccers.eth
I think it should be their choice. For many people this is an easy trade off given the deleterious effects of their prior obesity. They don’t need a snobby judgement on top!
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