Science

Accelerating the pace of science at @researchhubf | UC Riverside, Biomedical Science PhD

We're having our first AMA!

@jeffreykoury has graciously volunteered to cross the Rubicon.

Please post your questions under this cast, and Dr Koury will go through them on 02/21. Don't be shy!

He is theHead of the ResearchHub Foundation which is a community governed DAO that promotes incentivized open science. 

...

Working on building zkTLS infra/products. A ruthless empiricist and meme connoisseur.

/opacity
/eulerlagrange

Is dementia also present in HIV patients with undetectable viral loads from continued treatment?

Is the dementia linked to just having been infected, or to how long the virus stays detectable / untreated?

Great question. combination antiretroviral therapy (cART) can drop viral load to undetectable levels, however overall prevalence of HAND is unchanged. Albeit, we see more of the milder forms, and less of the severe forms. Can see Saylor et al 2016, Fig 2 for a nice schematic:

Aviator, diver, Etherean, nexialist, PhD in aviation ∩ climate science | Host of /diving /ethfinance /eth-staker /geopolitics /science /singapore /thomas

Great question. combination antiretroviral therapy (cART) can drop viral load to undetectable levels, however overall prevalence of HAND is unchanged. Albeit, we see more of the milder forms, and less of the severe forms. Can see Saylor et al 2016, Fig 2 for a nice schematic: https://pubmed.ncbi.nlm.nih.gov/26965674/

post-cART era, HAND wasn’t progressive (can check out a longitudinal study called CHARTER). Before cART it was progressive, and so the quicker one receives treatment the better. In fact, it takes about 1-2 weeks for detectable virus to make its way into brain/CSF, so catching it before that would be the most ideal.