hair

💈HDAC Inhibitors & Hair Loss: Are they a viable treatment? Specifically, can Valproic Acid (VPA) help? Let's dive in!

2/ 🧬 What are HDAC Inhibitors? Our DNA is wrapped around proteins called histones. Histone modifications via acetylase and deacetylase enzymes control which genes are expressed in our cells.

Network State solving hair loss💈👉 Join us on Discord: https://discord.gg/sNAm9QbfAz

3/ 🧠 Histone Acetylation: Acetylation causes histones to loosen their grip on DNA, upregulating gene expression. Deacetylation tightens this grip, silencing genes. HDAC inhibitors prevent deacetylation, thus increasing gene expression.

5/ 💊 Valproic Acid (VPA): The most studied HDAC inhibitor. A South Korean study showed that low-dose topical VPA increased hair count by 24 hairs/cm² compared to placebo. Promising!

6/ 🔍 Mechanism & Effects: VPA lowers PAI-1 and improves the PAI/tPA ratio, both positive for hair growth. However, there are concerns about systemic absorption and side effects, as it's originally an epilepsy drug.

7/ 🤔 Mixed Results: While the clinical trial was promising, a group buy conducted by our biohacker friends showed no regrowth. Systemic absorption can lead to severe side effects, and oral use has been linked to hair loss via a liver-activated effect.

8/ 🧪 Potential Combinations: Topical VPA might work best with other treatments like Verteporfin or Minoxidil. Researchers are exploring this!

9/ 🏥 Class II HDAC Inhibitors: Beyond VPA, Class II inhibitors like A364365, LMK235, Sodium butyrate, and Vorinostat are being studied. They may positively affect hair follicles but come with their own risks.

10/🫡 In summary, more research is needed but there is promise! That's where we come in...

This is the last cast. Beware of scammers 🙏

4/ ⚖️ HDAC Inhibitors vs. HAT Upregulators: While both can boost gene expression, inhibiting a protein (HDAC) is easier than upregulating one (HAT). This makes HDAC inhibitors a more practical focus for research.