Gross but practical question: how do you keep your external keyboard / mouse clean? 

I've tried isopropyl wipes and it doesn't seem that effective.

I have the same keyboard at work and at home but the one at home feels 100x nicer since I use it so much less.

Is it a lost cause?

Working on Farcaster and Warpcast. Longer thoughts at https://dwr.email

for keyboard: every month or so i take all the keycaps off and soak them in warm soapy water → then take them out → wipe them clean with a rag → put them back on the keyboard

for mouse: wet a rag and wipe it down, then dry (you prob need more friction than wipes)

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yes, I do the same too, but I think he uses the apple magic keyboard which you can't really take the keycaps out..