Why do anesthetics drugs get approved easily, even though treatment outcomes are hopelessly 'confounded' by surgery & functional unblinding is inevitable when testing them against placebo?

Because drug developers & regulators acknowledge that these are *tools*, not treatments.

Compass Pathways Pushes Back Phase 3 Readouts, Lays Off 30% of Staff

Here's my initial take... https://t.co/xKM0Vg4EYp

Josh Hardman

Why do anesthetics drugs get approved easily, even though treatment outcomes are hopelessly 'confounded' by surgery & functional unblinding is inevitable when testing them against placebo?

Because drug developers & regulators acknowledge that these are *tools*, not treatments.

https://x.com/Josh__Hardman/status/1851989465629163681