mario pfp

mario

@mario

79 Following
156 Followers
mario pfp
mario
@mario
best sentence i've written this year
6 replies
16 recasts
87 reactions
mario pfp
mario
@mario
"I see a near future where robots will be performing science 24/7." @wolfejosh shares a fascinating vision of cloud labs run by robots, where scientists can design experiments from an iPad on a beach. But there's a tension: while robotic precision could solve the reproducibility crisis in science, many breakthroughs historically came from "happy accidents." Listen to our full conversation: • YouTube: https://www.youtube.com/watch?v=us58WjbknsI • Spotify: https://open.spotify.com/episode/5WuovRYdA8enJZNWcBLwT7 • Apple: https://podcasts.apple.com/us/podcast/shrinking-the-gap-between-sci-fi-and-sci-fact-josh/id1805868710?i=1000703584700
0 reply
0 recast
0 reaction
mario pfp
mario
@mario
We explore: → The revolutionary development of genetically modified pig organs being transplanted into humans and what this means for the future of organ transplantation. → The recent achievement of "teleporting smell" across space and why computers that can replicate scents will open up entirely new industries. → Why Lux is investing in the search for real-life "X-Men" — genetic outliers in isolated populations whose DNA could lead to life-saving medical advancements. → How Josh evaluates macro trends to make smarter micro investment decisions and why ignoring the big picture is a mistake. → The three tech sectors that Josh believes will define the geopolitical balance in the decades ahead. → How Josh stays current on macroeconomic trends. …And much more!
0 reply
0 recast
0 reaction
mario pfp
mario
@mario
A big thank you to the incredible sponsors that make the podcast possible: ✨ Brex — The banking solution for startups: https://www.brex.com/mario ✨ WorkOS — The modern identity platform for B2B SaaS: https://workos.com/ ✨ Generalist+ — Essential intelligence for modern investors and technologists: https://thegeneralist.substack.com/
1 reply
0 recast
0 reaction
mario pfp
mario
@mario
Our latest episode is out, featuring @wolfejosh! "Shrinking the Gap Between Sci-Fi and Sci-Fact" Josh Wolfe is a Co-Founder of Lux Capital, where he funds the kinds of ventures that change everything: think gene-edited pig organs and technology that lets you “record” smells. His approach? Relentless curiosity. He reads dozens of newspapers daily to identify patterns, always staying a few steps ahead. In this episode of The Generalist, Josh shares how his firm backs companies that aren't just chasing where the world is going but actively creating where it needs to go. Listen now: • YouTube: https://www.youtube.com/watch?v=us58WjbknsI • Spotify: https://open.spotify.com/episode/5WuovRYdA8enJZNWcBLwT7 • Apple: https://podcasts.apple.com/us/podcast/shrinking-the-gap-between-sci-fi-and-sci-fact-josh/id1805868710?i=1000703584700
1 reply
0 recast
0 reaction
mario pfp
mario
@mario
at a nice lil london podcast studio! hope to do more IRL but the others have been out of my less swanky home office :)
0 reply
0 recast
0 reaction
mario pfp
mario
@mario
"On a per watt basis, humans are massively smarter than AI." Enjoyed this take on biological vs. silicon intelligence from Reid. Full episode: https://thegeneralist.substack.com/p/how-ai-will-enhance-human-potential-reid-hoffman
0 reply
0 recast
0 reaction
mario pfp
mario
@mario
hope you enjoy it! lmk if there are topics you think we should cover in future episodes :)
0 reply
0 recast
1 reaction
mario pfp
mario
@mario
The first episode of the new Generalist podcast is out, featuring Reid Hoffman :) Listen now: • YouTube: https://www.youtube.com/channel/UC5xRQOIT8cfumDr2HaKNd4g • Spotify: https://open.spotify.com/show/6mHuHe0Tj6XVxpgaw4WsJV • Apple: https://podcasts.apple.com/us/podcast/the-generalist/id1805868710
2 replies
2 recasts
2 reactions
mario pfp
mario
@mario
We explore: → Why Reid wrote Superagency, and his belief that AI leads to more human agency, not less → The philosophical questions raised by AI’s reasoning: Can machines truly think, or are they just mimicking us? → How generative AI promotes collaboration and creativity over passive consumption → Preserving humanity's essence as transformative technologies like gene editing and neural interfaces become mainstream → Reid’s optimistic take on synthetic biological intelligence as a symbiotic relationship → How AI agents can actually deepen human friendships rather than replace them → A glimpse at how Reid uses AI in his daily life → Reid’s “mini-curriculum” on science fiction and philosophy — two essential lenses for understanding AI’s potential …And much more!
0 reply
0 recast
1 reaction
mario pfp
mario
@mario
The first episode of the new Generalist podcast is out, featuring Reid Hoffman :) Listen now: • YouTube: https://www.youtube.com/channel/UC5xRQOIT8cfumDr2HaKNd4g • Spotify: https://open.spotify.com/show/6mHuHe0Tj6XVxpgaw4WsJV • Apple: https://podcasts.apple.com/us/podcast/the-generalist/id1805868710
2 replies
2 recasts
2 reactions
mario pfp
mario
@mario
Kirsten Green is one of the most thoughtful, rigorous investors I've ever met. I've loved learning from her through The Generalist's "Letters to a Young Investor" series. This edition is another classic, covering how Kirsten has built Forerunner from a solo-capitalist shop into a venture force. If you're interested in hearing how Kirsten approaches culture building, hiring, fund strategy, and more, jump in: https://thegeneralist.substack.com/p/kirsten-green-3
0 reply
0 recast
0 reaction
mario pfp
mario
@mario
I spent 9+ months interviewing 50 VCs, and turning their insights into a 138,000-word guide on how to succeed as a venture investor. That’s the equivalent of a 571-page book! Today, we’re sharing the full collection of pieces, along with a “Cheat Sheet” summarizing the main lessons. If you’re a VC that wants to hone your craft, an operator that wants to level up your angel investing, or a founder that needs to understand how the other side of the table thinks, my hope is that you’ll find this to be an invaluable resource. Jump in 👇 https://thegeneralist.substack.com/p/investors-guides-full-series
0 reply
0 recast
1 reaction
mario pfp
mario
@mario
“What I cannot create, I do not understand.” Richard Feynman’s blackboard at the time of his death.
0 reply
0 recast
0 reaction
mario pfp
mario
@mario
what a welcome! super generous of you 🙏
0 reply
0 recast
0 reaction
mario pfp
mario
@mario
🙏
0 reply
0 recast
1 reaction
mario pfp
mario
@mario
thanks so much, man! still building the muscle memory to come more frequently. thank you for the encouragement :)
0 reply
0 recast
0 reaction
mario pfp
mario
@mario
"When the typical economist tells me about his latest research, my standard reaction is, 'Eh, maybe.' Then I forget about it. When Robin Hanson tells me about his latest research, my standard reaction is, 'No way! Impossible!' Then I think about it for years." In our latest piece, I interview economist and polymath Robin Hanson. Robin shared his thoughts on terraforming Mars, cultural drift, fertility decline, and civilization's trajectory. Read more: https://thegeneralist.substack.com/p/robin-hanson
1 reply
0 recast
1 reaction
mario pfp
mario
@mario
The 6 steps to becoming an elite angel investor: 1. Lay the foundations – Study startups, build a "fantasy" VC portfolio 2. Know your motivations – Status? Learning? Track record? 3. Make a plan – Structure your approach 4. Start sourcing – Leverage your unique network 5. Play to your strengths – Move fast, add real value 6. Build a tribe – When and how to collaborate Full guide (17,500 words) with insights from investors in Canva, Oura, and Reddit: https://thegeneralist.substack.com/p/how-to-be-a-top-1-angel
3 replies
8 recasts
15 reactions
mario pfp
mario
@mario
not to me!
1 reply
0 recast
0 reaction