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mario

@mario

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@mario
best sentence i've written this year
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We explore: → The psychological biases that most frequently derail investors → Why the first-mover advantage is often a disadvantage in technology → Why excess funding often undermines innovation → The story of PayPal's near-death experience and how it sparked its most critical innovations → How Roelof’s training as an actuary shaped his long-term thinking → How Sequoia maintains investment discipline through market cycles → Why they don’t use the word “deal” at Sequoia → How the US can maintain the lead in the AI race → The thinking behind the Sequoia Capital Fund and the firm’s organizational structure …And much more!
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Listen now: • YouTube: https://www.youtube.com/watch?v=1oYXDK9xhb4 • Spotify: https://open.spotify.com/episode/6ybYkK1zFzHNEptrRC2eFU • Apple: https://podcasts.apple.com/us/podcast/lessons-from-20-years-of-venture-capital-roelof/id1805868710?i=1000705395843 A big thank you to the incredible sponsors that make the podcast possible: ✨ Brex — The banking solution for startups: https://www.brex.com/mario ✨ WorkOS — The modern identity platform for B2B SaaS: https://workos.com/mario ✨ Explo — Customer-facing analytics for any platform: https://www.explo.co/mario
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We're back with another great conversation, this time with Roelof Botha! "Lessons from 20 Years of Venture Capital: Roelof Botha (Managing Partner and Steward at Sequoia Capital)" Sequoia Capital is synonymous with outstanding performance, backing companies like Apple, Google, Airbnb, and Stripe. In our latest episode, I chat with Roelof Botha, Sequoia’s Managing Partner, about what it takes to see the future first, capitalize on it intelligently once it arrives, and help founders build enduring companies. Roelof is especially well-placed to discuss such matters. Not only has Sequoia navigated more than 50 years of market cycles, Roelof has personally spent more than 20 years helping shape the firm’s unique approach. From honing a philosophy rooted in clear thinking and long-term vision to asking the tough question of "What would you do with only 12 months of runway?" Roelof breaks down the mindset that’s helped Sequoia thrive, and what others can learn from it.
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"Failure comes from a failure to imagine failure." @wolfejosh shared this powerful insight on the podcast. The best leaders, entrepreneurs, and investors constantly ask: What could go wrong? How do I prevent it? It's not about pessimism but preparation. Listen to our full conversation: • YouTube: https://www.youtube.com/watch?v=us58WjbknsI • Spotify: https://open.spotify.com/episode/5WuovRYdA8enJZNWcBLwT7 • Apple: https://podcasts.apple.com/us/podcast/shrinking-the-gap-between-sci-fi-and-sci-fact-josh/id1805868710?i=1000703584700
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"If I was a foreign adversary concerned about a democracy thwarting my ambitions, I'd attack it from within – using its own freedoms against it." Fascinating insight from @wolfejosh on why information warfare has become the most critical space in geopolitics. Full episode: • YouTube: https://www.youtube.com/watch?v=us58WjbknsI • Spotify: https://open.spotify.com/episode/5WuovRYdA8enJZNWcBLwT7 • Apple: https://podcasts.apple.com/us/podcast/shrinking-the-gap-between-sci-fi-and-sci-fact-josh/id1805868710?i=1000703584700
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Just mind-blowing: @wolfejosh shared that scientists have successfully "teleported" smell for the first time: breaking down a plum's chemical essence, converting it to mathematical data, and recreating it elsewhere. The implications for healthcare are enormous. Think: machines that smell cancer, Parkinson's, and Alzheimer's markers. Listen to our full conversation: • YouTube: https://www.youtube.com/watch?v=us58WjbknsI • Spotify: https://open.spotify.com/episode/5WuovRYdA8enJZNWcBLwT7 • Apple: https://podcasts.apple.com/us/podcast/shrinking-the-gap-between-sci-fi-and-sci-fact-josh/id1805868710?i=1000703584700
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The numbers are striking: • 8 billion people on Earth • 10 people in space • Only *2* people with genetically engineered pig kidneys As @wolfejosh explains, xenotransplantation – the process of giving humans in need modified animal organs – represents a "directional arrow of progress that's inevitable." It could help save the lives of the 100K Americans waiting on donor transplants. Listen now: • YouTube: https://www.youtube.com/watch?v=us58WjbknsI • Spotify: https://open.spotify.com/episode/5WuovRYdA8enJZNWcBLwT7 • Apple: https://podcasts.apple.com/us/podcast/shrinking-the-gap-between-sci-fi-and-sci-fact-josh/id1805868710?i=1000703584700
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"I see a near future where robots will be performing science 24/7." @wolfejosh shares a fascinating vision of cloud labs run by robots, where scientists can design experiments from an iPad on a beach. But there's a tension: while robotic precision could solve the reproducibility crisis in science, many breakthroughs historically came from "happy accidents." Listen to our full conversation: • YouTube: https://www.youtube.com/watch?v=us58WjbknsI • Spotify: https://open.spotify.com/episode/5WuovRYdA8enJZNWcBLwT7 • Apple: https://podcasts.apple.com/us/podcast/shrinking-the-gap-between-sci-fi-and-sci-fact-josh/id1805868710?i=1000703584700
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We explore: → The revolutionary development of genetically modified pig organs being transplanted into humans and what this means for the future of organ transplantation. → The recent achievement of "teleporting smell" across space and why computers that can replicate scents will open up entirely new industries. → Why Lux is investing in the search for real-life "X-Men" — genetic outliers in isolated populations whose DNA could lead to life-saving medical advancements. → How Josh evaluates macro trends to make smarter micro investment decisions and why ignoring the big picture is a mistake. → The three tech sectors that Josh believes will define the geopolitical balance in the decades ahead. → How Josh stays current on macroeconomic trends. …And much more!
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A big thank you to the incredible sponsors that make the podcast possible: ✨ Brex — The banking solution for startups: https://www.brex.com/mario ✨ WorkOS — The modern identity platform for B2B SaaS: https://workos.com/ ✨ Generalist+ — Essential intelligence for modern investors and technologists: https://thegeneralist.substack.com/
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Our latest episode is out, featuring @wolfejosh! "Shrinking the Gap Between Sci-Fi and Sci-Fact" Josh Wolfe is a Co-Founder of Lux Capital, where he funds the kinds of ventures that change everything: think gene-edited pig organs and technology that lets you “record” smells. His approach? Relentless curiosity. He reads dozens of newspapers daily to identify patterns, always staying a few steps ahead. In this episode of The Generalist, Josh shares how his firm backs companies that aren't just chasing where the world is going but actively creating where it needs to go. Listen now: • YouTube: https://www.youtube.com/watch?v=us58WjbknsI • Spotify: https://open.spotify.com/episode/5WuovRYdA8enJZNWcBLwT7 • Apple: https://podcasts.apple.com/us/podcast/shrinking-the-gap-between-sci-fi-and-sci-fact-josh/id1805868710?i=1000703584700
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at a nice lil london podcast studio! hope to do more IRL but the others have been out of my less swanky home office :)
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"On a per watt basis, humans are massively smarter than AI." Enjoyed this take on biological vs. silicon intelligence from Reid. Full episode: https://thegeneralist.substack.com/p/how-ai-will-enhance-human-potential-reid-hoffman
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hope you enjoy it! lmk if there are topics you think we should cover in future episodes :)
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The first episode of the new Generalist podcast is out, featuring Reid Hoffman :) Listen now: • YouTube: https://www.youtube.com/channel/UC5xRQOIT8cfumDr2HaKNd4g • Spotify: https://open.spotify.com/show/6mHuHe0Tj6XVxpgaw4WsJV • Apple: https://podcasts.apple.com/us/podcast/the-generalist/id1805868710
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We explore: → Why Reid wrote Superagency, and his belief that AI leads to more human agency, not less → The philosophical questions raised by AI’s reasoning: Can machines truly think, or are they just mimicking us? → How generative AI promotes collaboration and creativity over passive consumption → Preserving humanity's essence as transformative technologies like gene editing and neural interfaces become mainstream → Reid’s optimistic take on synthetic biological intelligence as a symbiotic relationship → How AI agents can actually deepen human friendships rather than replace them → A glimpse at how Reid uses AI in his daily life → Reid’s “mini-curriculum” on science fiction and philosophy — two essential lenses for understanding AI’s potential …And much more!
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The first episode of the new Generalist podcast is out, featuring Reid Hoffman :) Listen now: • YouTube: https://www.youtube.com/channel/UC5xRQOIT8cfumDr2HaKNd4g • Spotify: https://open.spotify.com/show/6mHuHe0Tj6XVxpgaw4WsJV • Apple: https://podcasts.apple.com/us/podcast/the-generalist/id1805868710
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Kirsten Green is one of the most thoughtful, rigorous investors I've ever met. I've loved learning from her through The Generalist's "Letters to a Young Investor" series. This edition is another classic, covering how Kirsten has built Forerunner from a solo-capitalist shop into a venture force. If you're interested in hearing how Kirsten approaches culture building, hiring, fund strategy, and more, jump in: https://thegeneralist.substack.com/p/kirsten-green-3
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I spent 9+ months interviewing 50 VCs, and turning their insights into a 138,000-word guide on how to succeed as a venture investor. That’s the equivalent of a 571-page book! Today, we’re sharing the full collection of pieces, along with a “Cheat Sheet” summarizing the main lessons. If you’re a VC that wants to hone your craft, an operator that wants to level up your angel investing, or a founder that needs to understand how the other side of the table thinks, my hope is that you’ll find this to be an invaluable resource. Jump in 👇 https://thegeneralist.substack.com/p/investors-guides-full-series
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