mario

@mario

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best sentence i've written this year

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Just mind-blowing: @wolfejosh shared that scientists have successfully "teleported" smell for the first time: breaking down a plum's chemical essence, converting it to mathematical data, and recreating it elsewhere. The implications for healthcare are enormous. Think: machines that smell cancer, Parkinson's, and Alzheimer's markers. Listen to our full conversation: • YouTube: https://www.youtube.com/watch?v=us58WjbknsI • Spotify: https://open.spotify.com/episode/5WuovRYdA8enJZNWcBLwT7 • Apple: https://podcasts.apple.com/us/podcast/shrinking-the-gap-between-sci-fi-and-sci-fact-josh/id1805868710?i=1000703584700

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The numbers are striking: • 8 billion people on Earth • 10 people in space • Only *2* people with genetically engineered pig kidneys As @wolfejosh explains, xenotransplantation – the process of giving humans in need modified animal organs – represents a "directional arrow of progress that's inevitable." It could help save the lives of the 100K Americans waiting on donor transplants. Listen now: • YouTube: https://www.youtube.com/watch?v=us58WjbknsI • Spotify: https://open.spotify.com/episode/5WuovRYdA8enJZNWcBLwT7 • Apple: https://podcasts.apple.com/us/podcast/shrinking-the-gap-between-sci-fi-and-sci-fact-josh/id1805868710?i=1000703584700

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"I see a near future where robots will be performing science 24/7." @wolfejosh shares a fascinating vision of cloud labs run by robots, where scientists can design experiments from an iPad on a beach. But there's a tension: while robotic precision could solve the reproducibility crisis in science, many breakthroughs historically came from "happy accidents." Listen to our full conversation: • YouTube: https://www.youtube.com/watch?v=us58WjbknsI • Spotify: https://open.spotify.com/episode/5WuovRYdA8enJZNWcBLwT7 • Apple: https://podcasts.apple.com/us/podcast/shrinking-the-gap-between-sci-fi-and-sci-fact-josh/id1805868710?i=1000703584700

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Our latest episode is out, featuring @wolfejosh! "Shrinking the Gap Between Sci-Fi and Sci-Fact" Josh Wolfe is a Co-Founder of Lux Capital, where he funds the kinds of ventures that change everything: think gene-edited pig organs and technology that lets you “record” smells. His approach? Relentless curiosity. He reads dozens of newspapers daily to identify patterns, always staying a few steps ahead. In this episode of The Generalist, Josh shares how his firm backs companies that aren't just chasing where the world is going but actively creating where it needs to go. Listen now: • YouTube: https://www.youtube.com/watch?v=us58WjbknsI • Spotify: https://open.spotify.com/episode/5WuovRYdA8enJZNWcBLwT7 • Apple: https://podcasts.apple.com/us/podcast/shrinking-the-gap-between-sci-fi-and-sci-fact-josh/id1805868710?i=1000703584700

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"On a per watt basis, humans are massively smarter than AI." Enjoyed this take on biological vs. silicon intelligence from Reid. Full episode: https://thegeneralist.substack.com/p/how-ai-will-enhance-human-potential-reid-hoffman

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The first episode of the new Generalist podcast is out, featuring Reid Hoffman :) Listen now: • YouTube: https://www.youtube.com/channel/UC5xRQOIT8cfumDr2HaKNd4g • Spotify: https://open.spotify.com/show/6mHuHe0Tj6XVxpgaw4WsJV • Apple: https://podcasts.apple.com/us/podcast/the-generalist/id1805868710

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Kirsten Green is one of the most thoughtful, rigorous investors I've ever met. I've loved learning from her through The Generalist's "Letters to a Young Investor" series. This edition is another classic, covering how Kirsten has built Forerunner from a solo-capitalist shop into a venture force. If you're interested in hearing how Kirsten approaches culture building, hiring, fund strategy, and more, jump in: https://thegeneralist.substack.com/p/kirsten-green-3

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I spent 9+ months interviewing 50 VCs, and turning their insights into a 138,000-word guide on how to succeed as a venture investor. That’s the equivalent of a 571-page book! Today, we’re sharing the full collection of pieces, along with a “Cheat Sheet” summarizing the main lessons. If you’re a VC that wants to hone your craft, an operator that wants to level up your angel investing, or a founder that needs to understand how the other side of the table thinks, my hope is that you’ll find this to be an invaluable resource. Jump in 👇 https://thegeneralist.substack.com/p/investors-guides-full-series

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“What I cannot create, I do not understand.” Richard Feynman’s blackboard at the time of his death.

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"When the typical economist tells me about his latest research, my standard reaction is, 'Eh, maybe.' Then I forget about it. When Robin Hanson tells me about his latest research, my standard reaction is, 'No way! Impossible!' Then I think about it for years." In our latest piece, I interview economist and polymath Robin Hanson. Robin shared his thoughts on terraforming Mars, cultural drift, fertility decline, and civilization's trajectory. Read more: https://thegeneralist.substack.com/p/robin-hanson

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The 6 steps to becoming an elite angel investor: 1. Lay the foundations – Study startups, build a "fantasy" VC portfolio 2. Know your motivations – Status? Learning? Track record? 3. Make a plan – Structure your approach 4. Start sourcing – Leverage your unique network 5. Play to your strengths – Move fast, add real value 6. Build a tribe – When and how to collaborate Full guide (17,500 words) with insights from investors in Canva, Oura, and Reddit: https://thegeneralist.substack.com/p/how-to-be-a-top-1-angel

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lfg! gamechanging launch.

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Foxes, The sacred objects have arrived! Over the past few months, our skulk has learned the skill of garment making, embroidering, and printing. The result is the birth of the Philosophical Foxes mini-capsule collection. Jump in to snag something here and learn more below ↓ https://shop.philosophicalfoxes.com/

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Thought I'd try out sharing a Generalist piece on FC. This was an interview with Ho Nam, one of the world's best venture investors. What I love about Ho is that he's a purist -- he plays the game with the long term in mind and isn't interesting in chasing fads. https://thegeneralist.substack.com/p/ho-nam-1

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Farcaster is a special place.

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Update for the skulk: we've removed the Discord link from the website (for now), re-connected OS to correct Discord server, removed Discord link from Notion wiki, removed Discord link from X, and done a sweep through of other project links. Big thank you to @semui.eth @chriscocreated and @cassie for flagging so fast

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