What's the simplest way to set up a single static webpage that you can edit in Markdown and then converts to HTML? Want to minimize boilerplate templating code and other complexity.

Basically this, but not having to edit raw HTML.

What's the simplest way to set up a single static webpage that you can edit in Markdown and then converts to HTML? Want to minimize boilerplate templating code and other complexity.

Basically this, but not having to edit raw HTML. 

https://motherfuckingwebsite.com

The closest thing to this is GitHub Pages with Jekyll but there's a lot of overhead.

Could even be a CLI that converts Markdown to single HTML file and then uploads to server or whatever deploy workflow on Netlify?

A dumb approach would be to use pandoc to convert your markdown file to html directly. You can do it manually or setup a GitHub action to build the source repo and publish it to GitHub (or Cloudflare) pages branch.