longevity

there's a new paper on studying brain cells that change in aging mice

it says cells around the third ventricle like tanycytes that form the blood brain barrier are most affected by aging

but in the methods section my old labmates and i noticed they harvested cells from another source, under a reverse light/dark cycle 🤔 

1/?

Massive single-cell analysis of mice brains identifies nutrient-sensing and regenerative cell type in the hypothalamus as a main hub of brain aging.

In short: the analysis identified the energy homeostasis and nutrient sensing regulation center of the hypothalamus (the V3… https://t.co/4QOLco4bAy

Bryan Johnson /dd

there's a new paper on studying brain cells that change in aging mice

it says cells around the third ventricle like tanycytes that form the blood brain barrier are most affected by aging

but in the methods section my old labmates and i noticed they harvested cells from another source, under a reverse light/dark cycle 🤔 

1/?

https://x.com/bryan_johnson/status/1884345151411347649

neuroscience phd, DeSci advocate, interfaith chaplain. co-host of the /okbanger show and vibe imagineer for /christin. https://seemore.tv/christin

What is your alternative hypothesis (me too dumb to understand)

they scooped bits of the brain that they claim ages faster from...an entire different set of mice altogether that lived in the dark during the daytime and under lights during nighttime

so...it's unclear whether that is true or not

i also realize our disagreements are based on this xkcd comic

physics experiments are just much cleaner than biological ones b/c they don't involve scooping brain goop

weird internet kid. word rotator. building /seemore. yapping on /okbanger. curating in /cameron + pdfproject.org | dev + vet + HBS. 
seemore.tv/cameron 🫡

my strong assertion is make room for nuanced assertions and don't think they are weaker

There’s a good physics joke about assuming spherical cows somewhere out there

Basically I’m v comfortable with there being nuance + shades of grey but aggressively opposed to the notion that the shades should stop you from asserting things bc we live in an imperfect world and we need to maneuver within it w useful assumptions