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christin
@christin
there's a new paper on studying brain cells that change in aging mice it says cells around the third ventricle like tanycytes that form the blood brain barrier are most affected by aging but in the methods section my old labmates and i noticed they harvested cells from another source, under a reverse light/dark cycle 🤔 1/? https://x.com/bryan_johnson/status/1884345151411347649
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christin
@christin
in today's episode of the /okbanger show i told @cameron that there's a lot more nuance to science and facts are made of constructed opinions this is an example where if you look closely enough you can always draw an alternative hypothesis for the same data 2/?
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christin
@christin
the data is itself, fact but *how* the data is obtained and *what* can be concluded from the data is nuanced if i didn't coincidentally study the hypothalamus and have a labmate who later studied tanycytes, i might not have spotted the detail 3/?
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christin
@christin
(actually it's even more specifically coincidental, i studied circadian rhythm so i know that the inverse light/dark cycle will definitely affect the transcriptome and other measurements here) 4/?
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christin
@christin
@bryanjohnson (or his team) shared the paper, which makes sense b/c it is published in nature, the most reputable journal, from the allen brain institute, a very reputable research institution (funded by the microsoft paul allen) and this is the tricky thing about scientific findings--if we look at one paper it's very hard to draw conclusions, we need many replicating the same hypothesis through different experimental modalities 5/?
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