Bruno L. Cadilha pfp

Bruno L. Cadilha

@c-bl

25 Following
3 Followers
Bruno L. Cadilha pfp
Bruno L. Cadilha
@c-bl
First cast and thread. Why will science benefit from platforms like this one? - Coming from the field of cell therapy for hematology and oncology patients.
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Bruno L. Cadilha pfp
Bruno L. Cadilha
@c-bl
Material transfer agreements needed for tools that I had in my previous institution - legal department would take months to go through these so I'm better off generating the material anew.
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Bruno L. Cadilha pfp
Bruno L. Cadilha
@c-bl
For people doing synthetic biology which cloning tool and services do you use? I have been a fan of SnapGene and Twist bioscience for some years - are there better alternatives?
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Bruno L. Cadilha pfp
Bruno L. Cadilha
@c-bl
Had my research slot guaranteed starting April 2025 - next step finishing an animal experimentation protocol in the next couple of weeks.
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Bruno L. Cadilha pfp
Bruno L. Cadilha
@c-bl
I think as is, we have at best a decentralized funding for new IPs or launch of spinoffs/biotechs - which can both generate revenue somehow. What is the path towards funding basic, fundamental, explorative (you name it) research? I don't see it in current DeSci proposals
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Bruno L. Cadilha pfp
Bruno L. Cadilha
@c-bl
Joined last week! I'm Bruno, a resident in hematology and oncology, researching new cell engineering solutions to treat cancer and autoimmune diseases! I'll be trying to post often about my research projects.
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Bruno L. Cadilha pfp
Bruno L. Cadilha
@c-bl
Hi guys, I recently joined Farcaster and was looking for people interested in the same fields as I am - I'm a hematologist and oncologist resident in Germany. I mostly did research on tumor immunology. How about you guys?
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Bruno L. Cadilha pfp
Bruno L. Cadilha
@c-bl
There are numerous specializations within each cell type. Genetic programs can be visualised as sort of like skill-trees enabling proficiency for certain tasks. At times, labeling cells based on their function becomes a rather subjective exercise.
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Bruno L. Cadilha pfp
Bruno L. Cadilha
@c-bl
Help and coordination - Helper T cells - B cells and Plasma cells - Dendritic cells
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Bruno L. Cadilha pfp
Bruno L. Cadilha
@c-bl
Direct attack and killing - Effector T cells - Natural killer cells - Neutrophils
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Bruno L. Cadilha pfp
Bruno L. Cadilha
@c-bl
Regulation and suppression - Regulatory T cells - Macrophages - Myeloid Derived Suppressor cells
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Bruno L. Cadilha pfp
Bruno L. Cadilha
@c-bl
In this organised society called the immune system, there are cells that take on prominent roles - none are really accepted as unique nor exquisite to a specific cell type, but broadly accepted main roles.
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Bruno L. Cadilha pfp
Bruno L. Cadilha
@c-bl
The immune system is a common denominator in both cancer and autoimmune diseases. 1 - It constantly surveils, to promptly eliminate cells that deviate from their intended programs (cancer). 2 - Ensures that said surveillance and elimination events do not blow-out of proportions (autoimmunity).
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Bruno L. Cadilha
@c-bl
A gene engineering proposal in immune cells for the local ethics commission of my hospital! And did a little Lego with the 4yo.
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Bruno L. Cadilha pfp
Bruno L. Cadilha
@c-bl
Hi everyone! Wanted to give a shout-out here to find people working in bio-medicine. I spent the last decade working with T cells and antibodies and will start developing a project with frequent updates/discussions here on farcaster. Looking forward to connecting with anyone interested in the field!
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Bruno L. Cadilha pfp
Bruno L. Cadilha
@c-bl
But, with laboratory research (encompassing cells, mice, patient samples, viral vectors and DNA engineering) there is plenty of preparation that needs to be done in order to comply with regulatory agencies. I'll be reporting on all these aspects and building this project openly here. Let's go!
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Bruno L. Cadilha pfp
Bruno L. Cadilha
@c-bl
If things play out right, I can set up several research modules with potential to impact a broad range of immunological, haematological and cancer patients.
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Bruno L. Cadilha pfp
Bruno L. Cadilha
@c-bl
This year, I get to start working on a research project that aims at using T cells to deliver immunosuppression to inflammation sites.
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Bruno L. Cadilha pfp
Bruno L. Cadilha
@c-bl
In the meanwhile I'll do my little part and build my projects openly here. Appreciate all support!
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Bruno L. Cadilha pfp
Bruno L. Cadilha
@c-bl
I have seen multiple projects and DAOs working towards this goal. I hope some thrive and bring collaborative science to the next level. In the case of disease treatment, to me that ultimately means having a patient's interests above all else.
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