There’s a long list of historical leaders whose behavior signaled a rapid collapse of futures for corresponding empires.

Biden's type:

King George III: Mental struggles, possibly porphyria. Loss of American colonies, rise of constitutional monarchy.

Hindenburg: Cognitive decline, facilitated Nazi rise. Collapse of Weimar Republic.

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King Charles II (Spain): Inbreeding led to physical and mental disabilities. His reign saw the War of Spanish Succession, the division of the empire, and the decline of Habsburg Spain.

Emperor Ferdinand I (Austria): Suffered from epilepsy and possible hydrocephalus. His rule was marked by limited central authority and increased influence of regional nobility.

Tsar Nicholas II (Russia): Ineffective governance. His rule led to the Russian Revolution, the fall of the Romanov dynasty, and the rise of the Soviet Union.

Pope Clement VII: no specific illness just Indecision. His papacy saw the Protestant Reformation, weakened Papal authority, and a loss of political power.

Emperor Rudolf II (Holy Roman Empire): Suffered from melancholy and possible bipolar disorder. His reign saw the weakening of imperial authority, increased religious conflict, and the onset of the Thirty Years’ War.

King Louis XVI (France): Indecisiveness. His rule led to the French Revolution, the fall of the monarchy, and the rise of the First French Republic.