The Bar Lab Account pfp

The Bar Lab Account

@barlab

59 Following
5 Followers
The Bar Lab Account pfp
The Bar Lab Account
@barlab
Counter-drones dragging fishing-nets next?
0 reply
0 recast
0 reaction
The Bar Lab Account pfp
The Bar Lab Account
@barlab
Speaking frankly about the incentives may give them regulatory problems. Giving a worthless "gov" token to the community and letting the community put value, and maybe even extra utility, on top of it, is currently considered (right or wrong) a safer play. Don't blame the players, blame the game.
0 reply
0 recast
0 reaction
The Bar Lab Account pfp
The Bar Lab Account
@barlab
I try not to eat 18-20h/d, unless in social circumstances.
0 reply
0 recast
1 reaction
The Bar Lab Account pfp
The Bar Lab Account
@barlab
Be the 1/n you want to see in the world.
0 reply
0 recast
0 reaction
The Bar Lab Account pfp
The Bar Lab Account
@barlab
I'm all for little tweaks that make it less accessible and less publicly acceptable, but the freedom needs to remain.
0 reply
0 recast
0 reaction
The Bar Lab Account pfp
The Bar Lab Account
@barlab
Identifying sites with such a pattern is enough to speculate they might change with kidney functional decline. If you want to know if this happens in other tissues, checkout https://www.biorxiv.org/content/biorxiv/early/2023/05/07/2023.05.07.539727.full.pdf Thanks to Naor Sagy that did the work, and Oren Pleniceanu. .
0 reply
0 recast
0 reaction
The Bar Lab Account pfp
The Bar Lab Account
@barlab
The information theory of aging talks about how (epigenetic) information is lost. Here we show that in the kidney, this tissue specific signature is partially lost, and not randomly, but towards the common form in the body.
1 reply
0 recast
0 reaction
The Bar Lab Account pfp
The Bar Lab Account
@barlab
They are also highly enriched for tissue-specific enhancers. These sites become less accessible as tissue function declines.
1 reply
0 recast
0 reaction
The Bar Lab Account pfp
The Bar Lab Account
@barlab
in every single one of these sites, when kidney disease progresses, the methylation pattern changes towards the rest of the body. These sites are also enriched for specific transcription factors, and are associated with genes that change in kidney disease.
1 reply
0 recast
0 reaction
The Bar Lab Account pfp
The Bar Lab Account
@barlab
We wondered if it was just a coincidence. Turns out no. At least 72% of sites that display this unique methylation pattern correlated with kidney state. Now comes the really cool part:
1 reply
0 recast
0 reaction
The Bar Lab Account pfp
The Bar Lab Account
@barlab
between kidney state and methylation level (up to r=0.89). Looking at the top site for Glomerular Filtration Rate (GFR), we noticed something special
1 reply
0 recast
0 reaction
The Bar Lab Account pfp
The Bar Lab Account
@barlab
Using public datasets, we explored epigenetic clocks and methylation sites that correlate with kidney state and function in health and kidney disease. While some existing epigenetic clocks performed OK, many CpG sites had an exceptional correlation
1 reply
0 recast
0 reaction
The Bar Lab Account pfp
The Bar Lab Account
@barlab
Our manuscript about unique methylation patterns in the kidney is out https://rdcu.be/dytXU A short 🧵 Methylation levels at some CpG sites correlate with age and disease risk, but why these sites and not others?
1 reply
0 recast
1 reaction
The Bar Lab Account pfp
The Bar Lab Account
@barlab
Fundamentally - no. All you can know is that the validator follows the protocol, any extra data (like software version) cannot be verified.
0 reply
0 recast
1 reaction