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The Bar Lab Account
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Our manuscript about unique methylation patterns in the kidney is out https://rdcu.be/dytXU A short 🧵 Methylation levels at some CpG sites correlate with age and disease risk, but why these sites and not others?
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The Bar Lab Account
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Using public datasets, we explored epigenetic clocks and methylation sites that correlate with kidney state and function in health and kidney disease. While some existing epigenetic clocks performed OK, many CpG sites had an exceptional correlation
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The Bar Lab Account
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between kidney state and methylation level (up to r=0.89). Looking at the top site for Glomerular Filtration Rate (GFR), we noticed something special
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The Bar Lab Account
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We wondered if it was just a coincidence. Turns out no. At least 72% of sites that display this unique methylation pattern correlated with kidney state. Now comes the really cool part:
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