Sara
@wake-up-sara
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Research indicates that genetic factors significantly contribute to insulin resistance, with variations across Asian subgroups. For South Asians, studies suggest a lower ability to secrete insulin, linked to reduced beta-cell function, as noted in a review article (Why are South Asians prone to type 2 diabetes? A hypothesis based on underexplored pathways). This means their pancreas may struggle to produce enough insulin, leading to insulin resistance, especially under lifestyle challenges. For East Asians, a study highlights early beta-cell dysfunction, evident immediately after glucose ingestion, as a primary characteristic (Ξ² Cell Dysfunction vs Insulin Resistance in East Asians). This dysfunction, combined with genetic predisposition, makes East Asians more susceptible to insulin resistance at lower BMIs compared to Caucasians 0 reply
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