When reading about lifespan improvement in mice apply the 900 day rule.

Mice live to 900 days on average. If the treatment group doesn’t significantly surpass that, there’s not good evidence that it works.

In many studies the controls are short lived leading to the treatment looking better than it is.

Adding more glycine to the diet of mice produced a small but significant lifespan increase. It is an amino acid common in food, cheap, and sweet.

Restricting the amino acid isoleucine in the diet of mice produced significant lifespan extension

Rapamycin and acarbose produced the largest lifespan extension ever in the ITP. The earlier started the greater the effect.

They are safe, cheap, available, and the effect is probably preserved in humans.

This is the best bet we have today for lifespan extension.