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Paul Berg
@prberg
TLDR; for why intermittent rapamycin extends life. Aging is a quasi-programmed continuation of growth. mTOR (an enzyme) is the key regulator of growth, and it is present in all cells of the human body. Rapamycin inhibits mTOR, which slows down growth, which in turn slows down aging.
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mk
@mk
This isn’t correct. mTOR plays roles in cell proliferation, but it doesn’t slow aging by simply slowing growth. Also, rapamycin is immunosuppressive and can induce diabetes. It might have benefits but it’s not all upside.
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Paul Berg
@prberg
"slowing growth" might indeed be an accurate description of the what's going on. But what you said at the end is incorrect - intermittent rapamycin is NOT immunosuppressive and does NOT induce diabetes. See Blagosklonny's article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814615/
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Paul Berg
@prberg
Daily use of rapa inhibits both mTORC1 and mTORC2. Intermittent use (e.g. once-weekly, or twice per month) inhibits only mTORC1.
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Paul Berg
@prberg
Daily use of rapa inhibits both mTORC1 and mTORC2. Intermittent use (e.g. once-weekly, or twice per month) inhibits only mTORC1.
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