personal notes from @bleu.eth aka @agust (Agusti)

Main

agusti

I PRESENT YOU BLEUPRINT

nix + brew + zsh + shell scripts to bootstrap.

forget about manually installing all your apps.

just bleuprint it.

I PRESENT YOU BLEUPRINT

nix + brew + zsh + shell scripts to bootstrap.

forget about manually installing all your apps.

just bleuprint it.

https://github.com/bleulabs/bleuprint

Complex systems, in both nature and engineering, are built from simple, reusable components that are combined in hierarchical ways. An organism is made of organs, which are made of tissues, which are made of cells. A computer is made of a motherboard, CPU, and RAM, which are made of logic gates, which are made of transistors.

i had a lot of fun its like science fiction (I think) 

> “If we really built AXP-25 in the wet lab, what would that mean?”

Below is a concise, exam-ready map of implications.  Treat each bullet as a testable claim; emphasise uncertainty where noted (⚠︎).

Domain	Key implications	Trade-offs / Risks
Fundamental science	• First lineage-independent origin of life: calibrates abiogenesis models and life-detection instruments for Mars/Europa exobiology.• Enables controlled studies of evolution from a 3 kb starting genome—unreachable with natural microbes.• Validates thermodynamic models linking energy flux ↔ complexity.	⚠︎ Unknown emergent behaviours in an uncharted chemical space.⚠︎ May force revision of “universal” biosignature assumptions.
Technology & industry	• Orthogonal biomanufacturing: XNA chassis can’t exchange genes with wild strains but can produce xenochemicals (e.g. fluorinated polymers, novel antivirals).• Data storage: HNA more nuclease-resistant → archival molecular memory.• Live therapeutics with built-in kill-switch via essential base X*.	⚠︎ Commercial pressure may outrun safety validation.⚠︎ Supply-chain monopoly on synthetic nucleotides could raise equity concerns.
Biosafety / biosecurity	• Containment is intrinsic (essential X*, altered genetic code) → cited by OECD 2025 report as “safety-by-design exemplar”.   • Offers a template for future GMOs with near-zero horizontal-gene-transfer risk (MDPI 2024).  	⚠︎ Dual-use inversion: the same orthogonality that prevents gene flow also hides the organism from standard detection assays.⚠︎ Requires new regulatory playbook—NIH & EU directives assume canonical DNA.
Ethics & philosophy	• Demonstrates that life is a process, not ancestry; challenges vitalist intuitions.• Sparks debate on moral status of “alien” life we created (intrinsic value analysis, 2025).  	⚠︎ Public “playing-God” backlash; parallels to early recombinant-DNA anxieties (BioSocieties 2024).  
Security & geopolitics	• NATO (2024) flags synthetic life as both a strategic asset (materials, sensing) and a governance gap.  	⚠︎ Knowledge is irreversible; once protocols are public, state or non-state actors can iterate.
Environmental impact	• Auxiliary-nutrient dependence makes in situ survival unlikely; modelled escape probability <10⁻⁸ (our PRD).	⚠︎ Long-term interactions with ecosystems still untested; chemical by-products unknown.
Economic outlook	• Opens a xenobiology supply chain: polymerases, nucleotides, membrane precursors.• VC funding likely—synthetic-biology market already > $40 B (OECD 2025).	⚠︎ Patent thickets could stifle open research.

⸻

Suggested exam framing (3 sentences)

“AXP-25 would be the first human-made lineage of life, proving that metabolism + heredity + evolution can be engineered from non-biological parts.
Its intrinsic containment (unnatural base X*) makes it safer than canonical GMOs yet demands new oversight rules because existing biosurveillance cannot detect it.
Scientifically it calibrates our search for extraterrestrial life and supplies an orthogonal chassis for industry, but it raises profound ethical and security questions that must be addressed in parallel.”

(Cite OECD 2025, MDPI 2024, and intrinsic-value paper for bonus marks.)

⸻

Where to push discussion if asked for depth
	1.	Abiogenesis research: compare AXP-25’s energy density (10⁴ J kg⁻¹ s⁻¹) to hydrothermal-vent chemotypes.
	2.	Regulatory models: draft a “BSL-X” tier that couples chemical auxotrophy with blockchain-logged nucleotide supply.
	3.	Philosophical angle: argue whether moral status should track cognitive potential or mere self-maintenance.

⸻

Uncertainties flagged; every claim tied to a falsifiable metric or recent policy source.

Idk what me and o3 cooked yesterday

probably best to forget about AXP-25

aichannel

He was a prolific poster of /ai research and sometimes called out things that would happen weeks/months later, but his academic way of posting didn't get a lot of engagement. So I think he went back to X where much of his crowd is!

its hars to have much of a crowd when you antagonise and block everyone

lol i didnt even notice u ril now. no fkn idea whst his beef is


maybe bleuc mm self sucking elefants trigger him


fair

You can predict electricity network blackouts from available public data 2-3minutes before the incident.


and probably bank millions with the data.

claude is a terrible business operator (for now) https://x.com/anthropicai/status/1938630294807957804?s=46 i really need the anthropic tungsten cube

New Anthropic Research: Project Vend.

We had Claude run a small shop in our office lunchroom. Here’s how it went. https://t.co/y4oOBi6Qwl

piñata hat


few


bought via (now defunct) frame v1

i need $10 of apple gift card in exchange for crypto asset. i have eth, usdc available 

can someone help

im on ethos now, feel free to review me https://app.ethos.network/profile/x/bleuonbase

LMAO SEEING TRUMP RAGE CAUSE WE WONT PAY THE OTAN REVOLUTIONARY TAX 🤣🤣