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res ipsa ☺︎
@resipsa
fascinating itchiness feedback loop: histamine → stimulates sensory nerves → neuropeptides released → activate mast cells → histamine released histamine acting in skin and in the brain produce different effects. first-generation antihistamines (like Benadryl) are a non-selective H1 receptor antagonist that crosses the BBB and blocks both peripheral and central H1 receptors, which causes drowsiness via the CNS; whereas second-generation antihistamines (like Zyrtec) do not cross the BBB and bind peripheral H1 receptors primarily, largely avoiding effects to the CNS.
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