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Monteluna

@monteluna

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Occasionally I bounce over to LinkedIn and see an old coworker doing crazy stuff. This one was from Kuijjer who was a postdoc in the old Bioinformatics lab I worked for. tl;dr - Scientists have been trying to crack genetic regulatory networks for years to understand disease. The idea is that the genes themselves have evolved for thousands of years to express and repress genes, but they work in a network where one gene can form this network of interactions in many steps. This creates lots of analytical difficulties with targeting specific expressions since it's computationally hard to decipher how the genes interact. We had evidence of this when scientists realized Sickle Cell disease is exclusive to people of African origin. What's wild is they have assumed for years that many more networks are actually unique to individuals and groups of people, but now we can prove that is far more true than realized in cancer data. https://academic.oup.com/bib/article/26/4/bbaf315/8188241
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