Claus Wilke

@clauswilke

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We updated our survey of transfer learning with protein language models. Now it includes ESM C and AMPLIFY in addition to ESM-2 and ESMv. Quick conclusion: ESM C 600M is the model to use. But note reproducibility issues in next cast. 1/2 https://www.biorxiv.org/content/10.1101/2024.11.22.624936v2

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I made an interactive worksheet that provides a basic introduction to the R language. Meant for people that may be familiar with Python or other languages and want to understand some of the core concepts of how R works. https://wilkelab.org/SDS366/worksheets/intro-to-R.html This is part of my class on data visualization with R.

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Now published: We trained a chemical language model that works with both small molecules and peptides. Ideal for making predictions on peptides with non-standard amino acids or other chemical modifications. https://pubs.acs.org/doi/full/10.1021/acs.jcim.4c01441

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Sunset in Austin, TX.

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Get ready for Gen-AI-uary 2025, the AI version of this popular generative artists activity for the first month of each year. The prompts are available. Do one per day. Do them with AI. Post them in /ai-art. https://warpcast.com/piterpasma/0x1e9bdce8

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Are your students above average, well above average, outstanding, or truly exceptional? And how do they compare to the current students at MIT?

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The complete guide for transfer learning with the protein language model ESM-2. (In brief: Use ESM-2 650M and calculate mean embeddings across sites.) https://www.biorxiv.org/content/10.1101/2024.11.22.624936v1

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Oh wow, didn't expect this. Was there any news or any other identifiable catalyst?

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AI will replace programmers long before it replaces biologists. Excellent interview with the CEO of Anthropic. One of the few tech people who can actually competently talk about biology. Must watch if you're wondering how AI will shape our future. Don't be put off by the 5 hours. It's actually three interviews in one. I don't know why Fridman didn't split this up. Not nice towards the other two interviewees who aren't even mentioned in the title. https://www.youtube.com/watch?v=ugvHCXCOmm4

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Three open-rank positions at UT Austin: Cluster in Advances in Artificial Intelligence and Data Science for Environmental Systems Apply here: https://apply.interfolio.com/158908

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After a quarter century, MicroStrategy has finally made a new all-time high.

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I'd like to file a complaint. People told me that definitely Eth was cooked and so I thought I had more time to accumulate and now this. Can devs do something?

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AI is not a replacement for competent software developers. Listen to this (excellent) interview with the Cursor team. If somebody knows about AI-generated code it's them. It's obvious there is a huge opportunity for AI-assisted coding, but emphasis is on "assisted." The AI still needs a lot of hand-holding and human supervision. https://www.youtube.com/watch?v=oFfVt3S51T4

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We've turned on public mode for /ai-art. So for now everybody can cast, official channel members get priority. Channel rules still apply. https://warpcast.com/clauswilke/0xa5c7fd80

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Some general rules for /ai-art: 1. This is a channel for artists. Just because you made an image with AI doesn't mean it's art. Put some real effort and intent into your work. The mods have seen thousands of low-effort pieces and are happy to moderate accounts that post them. 2. Watch your casting cadence. If you're making multiple casts per hour and taking over the timeline chances are you'll be moderated. 3. When casting links to external minting sites (e.g. Rodeo club) make sure the artwork is clearly visible in your cast. You may have to add it to your cast separately; it depends on the site you're linking to. If your cast looks wrong delete it and cast again.

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Taking a break from channel signups. Will open up again soon.

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Mood yesterday vs mood today.

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Got quoted by Nate Silver on his most recent substack. https://www.natesilver.net/p/5545-is-a-really-close-race

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There seems to be a bug in the @warpcast web interface where if I go to a channel with a pinned cast and then immediately go to a different channel (via the channel side bar on the left) the pinned cast remains. @dwr.eth

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Every time I walk past this retainer wall I feel a bit uncomfortable.

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